I am listening to the OST for The Case Study of Vanitas and being reminded of just how great the anime was to watch. My feeling is that it is underrated, but I’m not sure it is really, but perhaps what it really is… is ‘unfound’ by it’s core audience that is clearly out there. For me it’s one of my great anime series of the last five years and does seemed to be loved by some, but not yet discovered by many.
A gentleman who cures Vampires of a condition that causes them to lose control and want to consume blood in an animal-like manner. There’s a backstory on how he received/learned the ability to do this, of course. And there are other characters that are Vampires that are interested in his tool and method of doing this since they see the tool he uses as the source of causing the behavior in the first place. It is animated beautifully, the music is truly stunning on every level. Battles are very good, not necessarily great. But set pieces are often great. There is a tremendous amount of fascinating, original world-building in the storytelling, but a few trope-like archetype characters here and there, most of which succeed and a few which do not.
It is very original from my perspective as both a fan of vampire fiction and anime. There is a lot of gender fluidity and not a lot of traditional fan service. The women who fight are largely covered from head to toe, as are most of the women otherwise throughout the series unless some story reason comes up (as does happen in one instance).
Character designs are great and both the Japanese and American voice casts do great jobs and you can watch in either sub or dub and be pretty happy with the outcome.