This post seems confusing without additional details. Maybe you can expand on what are the tasks that will make use of that kind of processing power. What are your performance priorities?
Based on your current description, I don’t see anything that will stress even a 10 year old CPU.
Also, what uses would you have for an egpu other than basic hardware acceleration? Gaming, A.I, etc…
If you just want to cover your bases, almost any high end x670 board will do the job.
https://www.techspot.com/bestof/amd-x670-motherboards
Hard to go wrong with the Asrock Taichi that Wendell from Level1Techs is also a fan of. Looks like memory will be your limiting factor and with VMs being part of the equation, 128gb seems like a good idea.
I am curious how well adobe software can use a dgpu in a vm. I understand things have gotten much better for gaming and maybe that’ll translate into other gpu intensive tasks.
A good source of info: https://forum.level1techs.com