The bottleneck is the CPU, I’ve the task manager always open and I see the CPU struggles a lot (RAM sometimes when I use too many VMs, SSD not at all).

Thanks for the suggestion, I’ll be careful about that.

I’ve had a look at that motherboards and they seems to only have 2 PCIe slots (I’ve checked the X670E and B650) About the GPU for the VMs, it can be passed through directly to them. I haven0t tried it yet, but it seems that a lot of people do so.

Well, actually my almost 10 years old i7-6700K struggles.
The problem is probably that I keep a lot of programs open:

• Outlook
• about 100 Firefox tabs (with 10+ addons)
• 10+ Chrome tabs
• 5 Edge tabs (with Excel 365)
• 3 or 4 Excel sheets
• MS Teams
• Foxit Reader
• a coupe of VMs
• QCAD/Photoshop/Premiere for basic editing (for these software I may need a discrete GPU)